Allegra (Fexofenadine) 60 mg and 180 mg Tablets: Non-Drowsy 24-Hour OTC Antihistamine for Hay Fever, Chronic Hives, and Allergic Rhinitis — Available Over the Counter, Non-Sedating

Information last reviewed: May 2026 — for educational purposes only.

Allegra is a brand-name antihistamine tablet containing fexofenadine hydrochloride, a second-generation H₁-receptor antagonist. It is indicated for seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives) in adults and children aged 6 years and older. Fexofenadine does not cross the blood-brain barrier to a significant degree, which accounts for its low-sedation profile compared with first-generation antihistamines.

What Is Fexofenadine?

Fexofenadine is the active metabolite of terfenadine. Unlike many earlier antihistamines, it selectively targets peripheral H₁ receptors without the cardiac side effects associated with its predecessor. The compound is excreted largely unchanged, meaning it has minimal interaction with the cytochrome P450 liver enzyme system — a relevant consideration for patients taking multiple medications.

Common allergy symptoms addressed include sneezing, itchy or watery eyes, nasal congestion, and skin itch related to urticaria. The onset of action is typically within one to three hours of an oral dose.

Over-the-Counter Availability

In many countries, including the United States, Canada, and the United Kingdom, fexofenadine tablets are available over the counter without a prescription in 60 mg and 180 mg strengths. The 180 mg tablet is the most commonly used adult formulation for once-daily dosing. In some jurisdictions and at higher doses (e.g., 180 mg twice daily for urticaria), a prescriber’s direction may be recommended.

Individuals with kidney impairment should consult a healthcare provider before using fexofenadine, as the drug is primarily eliminated renally and dosing adjustments may be appropriate.

Tablet Strengths and Forms

Fexofenadine is available in the following oral solid forms under the Allegra brand and as generics:

• 60 mg tablets — typically dosed twice daily; indicated for adults and children aged 12 and older
• 120 mg tablets — once-daily formulation available in some markets for seasonal rhinitis
• 180 mg tablets — once-daily adult dose; the most widely stocked OTC format
• 30 mg oral suspension — for children aged 6 to 11 years; also available as chewable tablets in certain markets

Generic fexofenadine tablets are bioequivalent to the brand and are subject to the same regulatory approval standards. Switching between brand and equivalent generic is generally straightforward, though patients should confirm the product with a pharmacist.

Price and Cost Considerations

The retail price of Allegra tablets varies by strength, pack size, and retailer. As a general reference, a 30-count pack of 180 mg Allegra OTC tablets typically retails in a mid-range price bracket at major pharmacy chains. Generic fexofenadine is available at a notably lower price point, and many pharmacy discount programs or store-brand equivalents offer further savings.

Insurance coverage for OTC antihistamines varies; in some cases, a prescription version may be covered by a health plan where the OTC equivalent is not. Patients with allergy-related benefit plans should verify with their insurer.

Frequently Asked Questions

Does Allegra cause drowsiness?

Fexofenadine has a low sedation rate in clinical studies, comparable to placebo. It is classified as a non-drowsy antihistamine. However, individual responses vary, and some people may still experience mild fatigue. Alcohol and other CNS depressants can amplify any sedating effect.

Is there a children’s Allegra?

Yes. Allegra is approved for children aged 6 and older. Children aged 6 to 11 typically use the 30 mg oral suspension or 30 mg chewable tablets (where available). The 60 mg and 180 mg tablets are intended for adults and children aged 12 and older.

What is the generic name for Allegra?

The generic name is fexofenadine hydrochloride. Generic versions produced by multiple manufacturers are sold under the INN (International Nonproprietary Name) and are approved as bioequivalent to the Allegra brand by regulatory authorities.

← Back to Allergy Medications