Information last reviewed: May 2026 — for educational purposes only.
What Is Zoloft (Sertraline)?
Sertraline, branded as Zoloft, is one of the most widely prescribed selective serotonin reuptake inhibitors (SSRIs) in the world. Like all SSRIs, it works by blocking the serotonin reuptake transporter (SERT), increasing synaptic serotonin concentrations. Sertraline has received FDA approval for the broadest range of psychiatric indications of any individual SSRI — covering depression, OCD, PTSD, panic disorder, social anxiety disorder (SAD), and premenstrual dysphoric disorder (PMDD). Its relatively short half-life compared to fluoxetine means discontinuation syndrome is more common if doses are missed or stopped abruptly.
Prescription (Rx) Status
Sertraline is prescription-only. Generic sertraline tablets are inexpensive and widely available. The brand Zoloft is also still marketed. Sertraline is approved for use in paediatric patients (ages 6+) for OCD. Like all antidepressants, the FDA black-box warning for suicidal ideation in young patients applies. Alcohol should be used cautiously or avoided during sertraline therapy.
Uses of Sertraline (Zoloft)
FDA-approved: major depressive disorder, OCD (adults and children 6+), post-traumatic stress disorder (PTSD), panic disorder, social anxiety disorder (SAD), and premenstrual dysphoric disorder (PMDD). Off-label uses include generalised anxiety disorder (GAD), binge eating disorder, and premature ejaculation (at low doses).
Tablet Strengths
Sertraline oral tablets: 25 mg, 50 mg, and 100 mg. Oral concentrate solution: 20 mg/mL. Typical starting dose for depression: 50 mg once daily. For PTSD or panic disorder, starting at 25 mg/day is often recommended. Titrate as needed; maximum dose: 200 mg/day. Take with or without food; the liquid concentrate should be diluted before use.
Price
Generic sertraline is very affordable. A 30-day supply of 50 mg tablets costs approximately $4–$15 at most major pharmacies. Many discount programmes offer it for under $10/month.
Frequently Asked Questions
Q: How long does sertraline take to work for anxiety?
A: Anxiety symptom reduction typically begins at 2–4 weeks; full effect for anxiety disorders may take 6–12 weeks. An initial transient increase in anxiety (jitteriness syndrome) can occur in the first 1–2 weeks — this is temporary and usually resolves.
Q: Can I drink alcohol while taking Zoloft?
A: Alcohol is not recommended as it can worsen depression, impair CNS function when combined with sertraline, and increase side effects. Modest social drinking may be tolerated in some individuals, but discuss with your doctor.
Q: What happens if I miss a dose of sertraline?
A: Take it as soon as you remember the same day. If it is almost time for the next dose, skip the missed dose. Missing multiple doses in a row can cause discontinuation symptoms (dizziness, nausea, flu-like feelings).
Disclaimer: This page is for informational purposes only and does not constitute medical advice. Sertraline requires a valid prescription. Always consult a qualified healthcare professional. See our full disclaimer.